Epigenetics: linking social and environmental exposures to preterm birth
نویسندگان
چکیده
منابع مشابه
Epigenetics and environmental exposures.
It is becoming increasingly apparent that genetic factors are inadequate to fully explain many processes that shape development and disease. For example, monozygotic twin pairs, despite sharing identical DNA sequences, are often discordant for many traits and diseases, indicating that the same genotype can give rise to distinct phenotypes. This points towards the involvement of additional facto...
متن کاملEnvironmental chemical exposures and human epigenetics.
Every year more than 13 million deaths worldwide are due to environmental pollutants, and approximately 24% of diseases are caused by environmental exposures that might be averted through preventive measures. Rapidly growing evidence has linked environmental pollutants with epigenetic variations, including changes in DNA methylation, histone modifications and microRNAs. Environ mental chemicals...
متن کاملPrenatal environmental exposures, epigenetics, and disease.
This review summarizes recent evidence that prenatal exposure to diverse environmental chemicals dysregulates the fetal epigenome, with potential consequences for subsequent developmental disorders and disease manifesting in childhood, over the lifecourse, or even transgenerationally. The primordial germ cells, embryo, and fetus are highly susceptible to epigenetic dysregulation by environmenta...
متن کاملEnvironmental epigenetics and phytoestrogen/phytochemical exposures.
One of the most important environmental factors to promote epigenetic alterations in an individual is nutrition and exposure to plant compounds. Phytoestrogens and other phytochemicals have dramatic effects on cellular signaling events, so have the capacity to dramatically alter developmental and physiological events. Epigenetics provides one of the more critical molecular mechanisms for enviro...
متن کاملEnvironmental phthalate exposure and preterm birth.
IMPORTANCE Preterm birth is a leading cause of neonatal mortality, with a variety of contributing causes and risk factors. Environmental exposures represent a group of understudied, but potentially important, factors. Phthalate diesters are used extensively in a variety of consumer products worldwide. Consequently, exposure in pregnant women is highly prevalent. OBJECTIVE To assess the relati...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2015
ISSN: 0031-3998,1530-0447
DOI: 10.1038/pr.2015.191